Dapagliflozin in elderly patients
WebDec 16, 2024 · Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE–TIMI 58 Study Introduction. Type 2 diabetes mellitus (T2DM) is a prevalent … WebApr 10, 2024 · Patients with T2DM who were given dapagliflozin for treatment for eight weeks experienced a reduction in liver fat and volume, according to the findings of a more recent randomised controlled trial. In addition, it has also come to light that lowering fibroblast growth factor 21 (FGF21) improves mitochondrial function [ 24 ].
Dapagliflozin in elderly patients
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WebJan 14, 2024 · Conclusions: Dapagliflozin reduced the risk of death and worsening heart failure and improved symptoms across the broad spectrum of age studied in DAPA-HF. There was no significant imbalance in tolerability or safety events between dapagliflozin and placebo, even in elderly individuals. WebDapagliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the …
WebApr 12, 2024 · However, in our study we found that relatively few patients aged ≥ 60 years were using SGLT2i, possibly because the elderly are more prone to various … WebSep 2, 2024 · PARIS – Proof that dapagliflozin significantly helped heart failure patients without diabetes recategorizes the drug as a major agent for treating HFrEF. DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug Journal of Clinical Outcomes Management
WebSep 19, 2024 · Among patients with heart failure and a reduced ejection fraction, those who received the SGLT2 inhibitor dapagliflozin had a lower risk of worsening heart failure or …
WebMar 30, 2024 · Farxiga (dapagliflozin) is a first-in-class, oral, once-daily sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in adults for the treatment of insufficiently controlled T2D as both monotherapy and as part of combination therapy as an adjunct to diet and exercise to improve glycaemic control, with the additional benefits of weight loss …
WebAug 21, 2024 · The SGLT2 inhibitor dapagliflozin (Farxiga) successfully met the primary endpoint of the phase 3 DAPA-HF trial in patients with heart failure, according to a press release from AstraZeneca.. DAPA-HF simon ree net worthWebJan 14, 2024 · In this study, empagliflozin showed a significant reduction in primary composite outcome of hospitalization for heart failure and cardiovascular death (19.4% versus 24.7%, HR 0.75 (0.65 to 0.86), NNT 19). The number of hospitalizations for heart failure were also reduced by empagliflozin (p < 0.001). simon ree options academy reviewhttp://mdedge.ma1.medscape.com/cardiology/article/206799/heart-failure/dapagliflozin-meets-primary-endpoint-dapa-hf-trial simon reed tennis commentatorWebOct 6, 2024 · Initiation of empagliflozin is not recommended for individuals ≥85 years of age due to the limited therapeutic experience. Dapagliflozin is licensed for T2DM, HFrEF and CKD, and it can be prescribed to older adults aged ≥65 years, with no dose adjustment required based on age [ 20 ]. simon ree tao of tradingWebMar 12, 2024 · On the other side, the use of canagliflozin, but not empagliflozin and dapagliflozin, has been associated with an increased risk of some adverse events, … simon reeve americasWebFor dapagliflozin Elderly (risk of volume depletion); hypotension; raised haematocrit; risk of volume depletion Cautions, further information Volume depletion Correct hypovolaemia … simon reeve mediterranean iplayerWebFeb 17, 2024 · Dapagliflozin may be preferred as an additional antidiabetic agent or alternative first-line agent in patients with heart failure or chronic kidney disease given the demonstrated cardiovascular and renal benefits (ADA 2024; DeSantis 2024; McMurray 2024; Wiviott 2024; Zelniker 2024). simon reeve bath forum