WebNov 27, 2024 · In Ggt1-Cre mice, Cre recombinase is expressed in RTECs 7–10 days after birth, and as a result Cre-mediated gene ablation is unlikely to influence normal renal development (32). Vgf PT−/− mice were indistinguishable from WT littermates and normal renal function was not evidently influenced by Vgf deficiency in RTECs ( Fig. S3 ). WebApr 5, 2014 · 目前已有的PEPCK-cre工具鼠仅有Hprttm1(Pck1-cre)Vhh变型启动子使肝中cre表达降低60%,而肝中cre表达提高10倍。 同时需注意此工具鼠中同时敲除了Hprt基 …
Acute Kidney Injury Instigates Malignant Renal Cell …
WebGgt1 Cre Transgenic Mice, supplied by The Jackson Laboratory, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - … WebThe genotyping protocol (s) presented here have been optimized for reagents and conditions used by The Jackson Laboratory (JAX). To genotype animals, JAX recommends researchers validate the assay independently upon receipt of animals into their facility. Reaction cycling temperature and times may require additional optimization based on the ... health plus dental
1101 Highway 171, Graceville, FL 32440 Trulia
WebFigure Legend Snippet: ( A ) Targeting construct was designed for integration into the ROSA26 region, and the expression cassette was designed with the CAG promoter-floxed stop codon-Trip13 cDNA-T2A-EGFP-polyA. 2A, protease cleavage site ( Trip13 cDNA was FLAG tagged at the 3′ end); CAG, CMV-IE enhancer/chicken β-actin/rabbit β-globin. ( B ) … WebFeb 5, 2012 · Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury. We also found that its deletion in the tubular epithelium leads to enhanced TGF-β1-Smad family member 3 (Smad3) signaling, epithelial damage and fibrosis, suggesting a protective role for Alk3-mediated signaling in the kidney. WebSep 17, 2024 · Selective deletion of Arg2 in endothelial cells (Tie2 Cre /Arg2 fl/fl) reduced the level of fibrosis after UUO. In contrast, selective deletion of Arg2 specifically in … health plus diagnostic centre delhi