WebJul 1, 2024 · Benzo [b]thiophene scaffold is one of the privileged structures in drug discovery as this core exhibits various biological activities allowing them to act as anti-microbial, anti-cancer,... WebCystine is formed as a dimer of cysteine, and these agents work by reducing the disulfide bond that bridges two molecules of cysteine. The thiol group combines with cysteine to form a more soluble cysteine–drug product combination that can be excreted.

Synthesis, Reactions and Medicinal Uses of Thiophene

WebThiophene-based analogs have been fascinated by a growing number of scientists as a potential class of biologically active compounds. Furthermore, they play a vital role for medicinal chemists to improve advanced compounds with a variety of biological effects. The current review envisioned to highlight some recent and particularly remarkable … WebJan 6, 2024 · A series of thiophene derivatives (TPs) were synthesized and evaluated for cytotoxicity in HepG2 and SMMC-7721 cell lines by MTT assay. TP 5 was identified as a potential anticancer agent based on its ability to inhibit tumor cell growth. Drawbacks of TPs, including poor solubility and high toxicity, were overcome through delivery using self … isithatha

Therapeutic importance of synthetic thiophene - BMC Chemistry

WebThe C2-position of thiophene is the most common site of attack. Nucleophilic reaction - Substituted thiophenes containing electron-withdrawing substituents have a much higher … WebJul 19, 2024 · Rheumatoid arthritis, arthrosis and gout, among other chronic inflammatory diseases are public health problems and represent major therapeutic challenges. Non-steroidal anti-inflammatory drugs (NSAIDs) are the most prescribed clinical treatments, despite their severe side effects and their exclusive action in improving symptoms, … WebJan 1, 2012 · Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal … kerstmusical scrooge